Composition

• Each Tablet Contains:
• Amoxycillin 500 mg
  Clavulanic Acid 125 mg

Packing

• 10X1X10
  Alu-Strip
  

MRP

• 205

Overview

Amoxicillin is a semi synthetic penicillin with a broad spectrum bactericidal activity, and has good oral absorption.It acts through the inhibition of biosynthesis of cell wall.

Potassium Clavunate It act as a inhibitor of Β-lactamases of Gram +ve and Gram -ve pathogenic bacteria.
Has a protective effect on Amoxicillin Clavulanic acid when combined with Amoxicillin extends the antibacterial spectrum of Amoxicillin to include organisms resistant to Amoxicillin and other beta-lactam antibiotics, It has been demonstrated by recent studies that Amoxycillin and potassium clavunate shows significantly better symptoms relief with the modest improvement of Upper and lower respiratory tract infections.

Indications

Amoxicillin and Potassium clavunate is used in the treatment of a number of infections including:

• Upper and lower respiratory tract infection.
• Otitis Media (inflammation of the middle ear).
• Acute Sinusitis.
• Acute exacerbation of chronic bronchitis.
• Pneumonia.
• Urinary tract infection.

Mechanism of action

Penicillin-like antibiotic Amoxicillin works by stopping the growth of bacteria. Potassium clavunate works by preventing bacteria from destroying amoxicillin.

Pharmacokinetics

Clavulanic acid binds and inhibits beta-lactamases that inactivate amoxicillin resulting in amoxicillin having an expanded spectrum of activity. Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin- binding proteins which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Side Effects

Side effects of Amoxicillin and Potassium clavunate is generally minor and well tolerated:

• Diarrhea/loose stools
• Nausea
• Vomiting
• Headache

Contraindication

Amoxicillin and potassium clavunate is contraindicated in patients with a history of allergic reactions to any penicillin. It is also contraindicated in patients with a previous history of cholestatic jaundice.

Precaution

Carefully use this product in the following conditions:

• Arrhythmia
• Electrolyte imbalance
• Hypercalcemia
• Renal dysfunction
• Hepatobiliary dysfunction